CJC-1295 | Reviews, Clinical Trials, and Safety
CJC-1295, a synthetic analogue of GHRH and growth hormone secretagogue (GHS), is widely studied for its role in growth hormone deficiency, sleep enhancement, and anti-aging. Explore key clinical findings and benefits in this comprehensive research-focused review.
CJC-1295 Overview
Category:
Peptide
How It Works:
CJC-1295 interacts with specific receptors in the pituitary gland, triggering the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) over an extended period.
Key Studies:
- Once-daily Administration of Cjc-1295, a Long-acting Growth Hormone-releasing Hormone (GHRH) Analog, Normalizes Growth in the GHRH Knockout Mouse
- Sleep and Endocrine Changes After Intranasal Administration of Growth Hormone-releasing Hormone in Young and Aged Humans
- A Method for Confirming Cjc‐1295 Abuse in Equine Plasma Samples by LC–MS/MS
Primary Research Focus:
- Addressing growth hormone deficiencies
- Enhancing body composition
- Supporting anti-aging and sleep improvement
Alternative Names:
UNII-62RC32V9N7, 62RC32V9N7
Potential Risks:
- Limited data from human studies
- Not FDA-approved for general use
- Included on the WADA Prohibited List
Chemical Structure:
What is CJC-1295?
CJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH) and a growth hormone secretagogue (GHS). It was developed in the mid-2000s by ConjuChem Technologies and is widely recognized in research for its potential applications in growth hormone deficiency, sleep enhancement, and longevity studies.
Initially created to address obesity-related issues in HIV/AIDS patients, CJC-1295 has gained attention for its ability to stimulate growth hormone production. Its unique feature lies in the Drug Affinity Complex (DAC) technology, which significantly prolongs its half-life by enabling stronger binding to blood proteins. The standard CJC-1295 peptide, composed of 29 amino acids, has been further refined with DAC to improve its efficacy and duration.
Notably, some confusion surrounds the variations of CJC-1295 available on the market. The original peptide developed by ConjuChem contained DAC, but other manufacturers later produced versions without DAC. These are often labeled as “CJC-1295 Without DAC” or “CJC-1295 No DAC” to distinguish them.
While CJC-1295 shows promise in scientific studies, it remains an investigational compound. It is not approved by the FDA and is available only for research purposes. This article will explore its mechanisms, benefits, and potential applications, offering researchers a comprehensive look into this intriguing peptide.
What Does CJC-1295 Do?
CJC-1295 interacts with receptors in the pituitary gland to trigger the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). These hormones play crucial roles in regulating various physiological processes, including growth, metabolism, and recovery.
The peptide mimics the action of natural growth hormone-releasing hormone (GHRH), leading to increased GH secretion. However, what sets CJC-1295 apart is its extended duration of action. The addition of Drug Affinity Complex (DAC) significantly extends its half-life, allowing GH levels to remain elevated for longer periods compared to alternatives like sermorelin.
Without DAC, CJC-1295 has a very short half-life of about 30 minutes. With DAC, its half-life ranges from 6 to 10 days. This extended duration provides a sustained release of GH and IGF-1, enhancing its potential for applications in research.
Animal studies have confirmed that CJC-1295 binds to receptors in the anterior pituitary gland, activating growth hormone pathways. Its prolonged action makes it a promising tool for studies on muscle growth, fat metabolism, and sleep regulation.
C-1295 Benefits | Clinical Trials
CJC-1295 has gained attention in scientific research for its ability to elevate growth hormone (GH) levels and improve various physiological processes. Researchers are particularly interested in its potential for muscle growth, fat metabolism, and sleep enhancement.
CJC-1295 Enhance Muscle Growth
CJC-1295’s ability to boost growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels has made it a subject of great interest for muscle research. These hormones play a central role in protein synthesis, the process critical for building and repairing muscle tissue.
Preliminary studies suggest that CJC-1295 promotes anabolic activity, potentially increasing muscle mass and aiding recovery. This could make it beneficial in studying muscle-wasting conditions, recovery after injury, or aging-related muscle loss.
To maximize effects, researchers often pair CJC-1295 with ipamorelin. The combination enhances protein synthesis and muscle repair while potentially offering synergistic benefits.
Key insights from research include:
- Stimulated protein synthesis for muscle growth.
- Enhanced muscle recovery after physical stress or injury.
- Improved retention of muscle mass during aging.
- Synergistic results when combined with ipamorelin.
While promising, these benefits require further research to determine long-term effects and broader applications in human models.
CJC-1295 Improve Fat Metabolism
The role of CJC-1295 in fat metabolism has been explored in various studies, with researchers focusing on its ability to regulate hormonal pathways. One of its significant effects is the normalization of prolactin, a hormone associated with fat accumulation in certain conditions.
Animal studies, including research involving GHRH knockout mice, suggest that CJC-1295 promotes effective fat metabolization. This highlights its potential as a tool for studying obesity and metabolic disorders.
Additionally, the combination of CJC-1295 with GHRP-2 has shown even greater promise. GHRP-2 activates a different receptor in the growth hormone pathway, working synergistically with CJC-1295 to enhance fat loss.
Notable benefits of this peptide combination include:
- Improved breakdown of stored fat.
- Reduction in visceral fat accumulation.
- Increased metabolic efficiency and energy expenditure.
- Potential improvements in cardiovascular and immune health.
- Enhanced body composition through fat-to-muscle ratio shifts.
These findings underscore CJC-1295’s potential as a key peptide in fat metabolism research, although more human studies are needed to validate these effects.
CJC-1295 Support Restorative Sleep
CJC-1295’s role in sleep regulation has made it a compelling area of study. By mimicking natural growth hormone-releasing hormone (GHRH), it plays a potential role in improving sleep quality, which is crucial for recovery and overall health.
A study by Fehm et al. investigated the effects of intranasal GHRH on sleep in healthy male participants, divided into young and elderly groups. Participants were administered GHRH or a placebo 30 minutes before bedtime, with sleep monitored throughout the night.
The results were significant:
- Increased rapid-eye-movement (REM) sleep phases.
- Enhanced slow-wave sleep (SWS), particularly in the latter half of the night.
- Stabilized hypothalamic hormone secretory activity.
- Reduced cortisol levels early in sleep.
These findings suggest that GHRH, and by extension CJC-1295, supports dual neuronal and endocrine roles during sleep. This peptide's potential to promote restorative sleep extends to its ability to improve non-REM sleep. Non-REM sleep, often linked to growth hormone release, aids muscle recovery and overall physical restoration.
Furthermore, GH is known to enhance sleep quality after periods of deprivation. For researchers exploring sleep regulation, CJC-1295 could serve as a valuable tool in studying disorders, recovery, and aging-related sleep challenges.
While the benefits are promising, long-term studies are needed to confirm CJC-1295’s role in improving sleep across different models.
CJC-1295 Side Effects
Research into CJC-1295 has uncovered several mild, self-reported side effects among participants. These effects vary in intensity and may include:
- Headaches: Common among participants, possibly linked to hormonal fluctuations.
- Nausea: Some users report mild stomach discomfort.
- Hives: A potential allergic reaction in sensitive individuals.
- Anxiety: Rare but noted in certain cases during peptide use.
- Irritability: Observed as a transient mood change.
- Flu-like symptoms: General fatigue and malaise resembling the common flu.
During its initial development, CJC-1295 was studied as a treatment for HIV-associated lipodystrophy. Although one participant in a trial tragically passed away, the attending physician determined that the death was unrelated to the peptide itself. However, this incident underscores the need for more thorough studies to establish the peptide’s complete safety profile.
Is CJC-1295 Safe?
Initial studies suggest that CJC-1295 exhibits a favorable safety profile for short-term use. Researchers have observed that the peptide is generally well-tolerated, with no significant adverse effects reported during early trials.
Nonetheless, concerns remain about its extended half-life, which ranges from 6 to 10 days. This prolonged activity may pose risks for long-term administration, as sustained hormone release could lead to unintended consequences.
To conclusively determine its safety, comprehensive phase 1 trials with independent validation are essential. Such studies would provide crucial data to evaluate the peptide’s safety over longer durations and in diverse research settings.
CJC-1295 Dosage Calculator
The dosage guidelines for CJC-1295 are primarily based on two 2006 studies by Teichman et al. These studies examined healthy participants aged 21 to 61 using randomized, placebo-controlled, and double-blind methods.
Key findings from the studies include:
- Study 1 (28 days): Participants received one of four ascending single doses of CJC-1295 or placebo.
- Study 2 (49 days): Subjects were administered two or three doses weekly or biweekly.
Results demonstrated that plasma growth hormone (GH) levels increased by 2- to 10-fold for over six days, while IGF-1 concentrations rose by 1.5- to 3-fold for 9 to 11 days.
The tolerable dose range identified in these studies was between 30 and 60 μg/kg. While these findings are promising, further research is needed to refine dosage guidelines and confirm long-term tolerability.
Where to Buy CJC-1295 Online? | 2024 Edition
Finding a dependable source for CJC-1295 is vital for researchers. A trustworthy vendor ensures that peptides are of the highest quality, supporting the integrity and success of research projects.
After evaluating multiple suppliers, we’ve identified those offering exceptional standards in product quality, transparency, and service. Reliable vendors not only provide pure peptides but also guarantee efficient shipping and customer support. Researchers deserve the best, and sourcing from a trusted supplier is the first step to achieving reliable results.
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CJC-1295 DAC | CJC-1295 No DAC | CJC-1295 No DAC + Ipamorelin
Whether the focus is on CJC-1295 DAC, CJC-1295 No DAC, or a blend of CJC-1295 No DAC and Ipamorelin, selecting the right vendor is critical. Each formulation serves unique research purposes, but their efficacy depends on consistent quality.
For outstanding service and reliable product quality, one vendor stands above the rest:
Limitless Life
Limitless Life is widely regarded as a top-tier vendor for researchers sourcing CJC-1295. This supplier’s dedication to quality, efficiency, and ethical practices makes it an ideal choice for professionals in the field of peptide research.
Key features that set Limitless Life apart include:
- Independent Quality Testing: All products undergo rigorous independent laboratory testing, ensuring a purity rating of 99% or higher. This commitment to quality provides confidence to researchers who rely on these peptides for their studies.
- Exceptional Customer Service: Available seven days a week, their support team is ready to address inquiries, resolve issues, and assist with orders quickly and efficiently.
- Fast and Reliable Shipping: Domestic orders are shipped within 48 hours using FedEx, while international shipping is designed to be quick and dependable, accommodating researchers worldwide.
- Recognized Excellence: Limitless Life is accredited by the Better Business Bureau (BBB) and Dun & Bradstreet for their ethical and transparent business operations.
To access CJC-1295 and other peptides, consider joining the Limitless Biotech site. Becoming a VIP member is free. You only have to create an account or log in to get started.
Bacteriostatic Water and CJC-1295
Proper preparation and handling of peptides like CJC-1295 are essential for maintaining research accuracy and reliability. Top researchers understand that having the right supplies in the lab is just as important as the peptides themselves.
What tools are needed? A variety of essential items, including:
- Bacteriostatic Water: Used to dilute and prepare peptides for precise measurements.
- Sterile Empty Glass Vials: Necessary for mixing and storing peptides without contamination.
- Insulin Syringes: Ideal for accurate and controlled dosing in experiments.
- Large Needles and Syringes: Useful for transferring and reconstituting larger volumes.
- Alcohol Prep Pads: Ensure surfaces and tools are sanitized before handling materials.
- Latex or Nitrile Gloves: Protects both researchers and samples from contamination.
- Proper Storage Containers: Maintain the stability and integrity of peptides during storage.
For researchers lacking these tools, authorized vendors offer high-quality supplies that meet research-grade standards. Reliable equipment is the foundation for successful peptide experiments.
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Frequently Asked Questions (FAQ)
Yes, research suggests that CJC-1295 increases growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels. These hormones are known to support muscle growth, which may make this peptide beneficial for studies focusing on muscle development.
No direct evidence links CJC-1295 to weight gain. On the contrary, studies indicate that it may aid in fat loss by regulating prolactin levels, potentially improving body composition.
CJC-1295 is available for purchase by qualified researchers as a reference material for laboratory experiments. It is not approved for general public use or clinical application.
Once reconstituted with bacteriostatic water, CJC-1295 is typically administered subcutaneously to test subjects for research purposes.
CJC-1295 does not increase testosterone. Instead, it elevates serum GH and IGF-1 levels, which are linked to other metabolic and physiological benefits.
Short-term studies suggest that CJC-1295 is relatively well-tolerated, with no severe adverse events reported. However, its long-term safety profile is yet to be thoroughly established.
This peptide is reconstituted using sterile or bacteriostatic water, which preserves its integrity during preparation.
CJC-1295 has been shown to improve GH and IGF-1 levels, making it a peptide of interest in studies on body composition, anti-aging, and sleep enhancement.
Yes, it is a legitimate peptide used widely in research. Its effects on growth hormone levels and other areas of interest have been documented in scientific studies.
CJC-1295 | Key Reviews
CJC-1295, originally developed by ConjuChem Technologies, has proven to be a groundbreaking peptide with applications in growth hormone research, muscle development, fat metabolism, and sleep enhancement.
From its ability to stimulate GH and IGF-1 to its extended half-life enabled by DAC technology, CJC-1295 remains a promising focus for scientific exploration. Despite its potential, researchers must consider its investigational status, emphasizing the need for thorough safety studies and proper handling.
To explore CJC-1295 and other peptides, join the Limitless Biotech site. Becoming a VIP member is free. Simply create an account or log in to get started.
References
- Alba, M., Fintini, D., Sagazio, A., Lawrence, B., Castaigne, J. P., Frohman, L. A., & Salvatori, R. (2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American Journal of Physiology-Endocrinology and Metabolism, 291(6), E1290-E1294.
- Baker, R. C., Implementing‘Moral, R. W. B. I., Noel, P., Ass, W. N. S. D. S., Nirenberg, M., Con, C., ... & Exposé, H. (2024). VOICE OF THE AGES. Image.
- Gellar, S. (2022). Peptides: substances of tomorrow–Moving beyond the traditional framework of Performance Enhancing Drugs (PEDs). British Society of Criminology Newsletter, 27.
- Ionescu, M., & Frohman, L. A. (2006). Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. The Journal of Clinical Endocrinology & Metabolism, 91(12), 4792-4797.
- Memdouh, S., Gavrilović, I., Ng, K., Cowan, D., & Abbate, V. (2021). Advances in the detection of growth hormone releasing hormone synthetic analogs. Drug Testing and Analysis, 13(11-12), 1871-1887.
- Next Generation Medicines from Therapeutic Peptides | ConjuChem LLC. Conjuchem.com. (2021). Retrieved 13 March 2021, from http://www.conjuchem.com/.
- Perras, B., Marshall, L., Köhler, G., Born, J., & Fehm, H. L. (1999). Sleep and endocrine changes after intranasal administration of growth hormone-releasing hormone in young and aged humans. Psychoneuroendocrinology, 24(7), 743-757.
- Sackmann-Sala, L., Ding, J., Frohman, L. A., & Kopchick, J. J. (2009). Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Hormone & IGF Research, 19(6), 471-477.
- Timms, M., Ganio, K., & Steel, R. (2019). A method for confirming CJC‐1295 abuse in equine plasma samples by LC–MS/MS. Drug Testing and Analysis, 11(8), 1248-1257.
- Van Hout, M. C., & Hearne, E. (2016). Netnography of female use of the synthetic growth hormone CJC-1295: pulses and potions. Substance Use & Misuse, 51(1), 73-84.